Sotrastaurin Acetate
Information
- Drug Name
- Sotrastaurin Acetate
- Description
- Entry(CIViC)
- 2
CIViC
| Disease | Mutation | EL | ET | ED | CS | VO | TR | Pubmed | Links |
|---|---|---|---|---|---|---|---|---|---|
| uveal melanoma | GNA11 MUTATION GNA11 MUTATION | D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 3 | 24141786 | Detail |
| uveal melanoma | GNAQ MUTATION GNAQ MUTATION | D |
Predictive
|
Supports
|
Sensitivity/Response | Somatic | 4 | 24141786 | Detail |
Annotation
| Description | Associated Genes | Associated Variants | Sensitivity | Supported | Source | Links |
|---|---|---|---|---|---|---|
| Preclinical study in uveal melanoma. Increased PKC... | GNA11 | GNA11 MUTATION GNA11 MUTATION | Sensitivity | true | CIViC Evidence | detail |
| Preclinical study in uveal melanoma. Increased PKC... | GNAQ | GNAQ MUTATION GNAQ MUTATION | Sensitivity | true | CIViC Evidence | detail |
| NCT ID | Status | Phase | Summary | Start date | Completion date |
|---|---|---|---|---|---|
| NCT02285244 | Withdrawn | Phase 2 | Sotrastaurin Acetate in Treating Patients With Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Leukemia, Prolymphocytic Leukemia, or Richter's Transformation | March 12, 2015 | March 12, 2015 |